Histopathology Session V DENT4217 **Soft tissue (mesenchymal) tumours** **A/Prof Omar Kujan** Case 1 • Slide ID 1068 • Image ID 718 Histological image of tissue section stained with hematoxylin and eosin (H&E).  Histopathology image showing inflammatory and fibrotic tissue response.  Microscopic description * Lobular pattern of vascular proliferation with inflammation and edema resembling granulation tissue * Thin epidermis at top with variable ulceration * Acanthosis and hyperkeratosis at sides * Central branching vessel is called capillary or vascular lobule, with no / rare red blood cells, surrounded by endothelial cells * Variable mitotic activity * Deep lesions often lack edema and inflammation Diagnosis • Pyogenic granuloma No text found in the image.  Case 2 • Slide ID 1069 • Image ID 719 Histological section of tissue stained with H&E (hematoxylin and eosin), showing epithelial and connective tissue layers.  No text is detected in the image.  # Microscopic description * Fibrous tissue proliferation * Inflammatory infiltrate Diagnosis • Fibroepithelial polyp No text detected in the image.  Case 3 * Slide ID 1070 * Image ID 720 No text detected in the image.  There is no extractable text content in this image. It appears to be a microscopic image of biological tissue.  Microscopic description * Epithelial hyperplasia * Fibrous tissue proliferation * Inflammatory infiltrate # Diagnosis * Denture related hyperplasia Clinical intraoral photographs showing a lesion on the palate.  Case 4 • Slide ID 1073 • Image ID 723 No text detected in the image.  No text detected in the image.  **Microscopic description** * Biphasic: compact hypercellular Antoni A areas and myxoid hypocellular Antoni B areas (may be absent in small tumors) * Cells are narrow, elongate, wavy with tapered ends interspersed with collagen fibers * Nuclear palisading around fibrillary process (Verocay bodies) are often seen in cellular areas * Large irregularly spaced vessels are most prominent in Antoni B areas * Gaping tortuous lumina have thickened hyalinized walls and may have thrombi * Tumor cells have ill defined cytoplasm, dense chromatin * May have foamy macrophages * Often displays degenerative nuclear atypia (ancient change) * Amianthoid fibers or collagenous spherules: large nodular masses of collagen with radiating edges * Rarely epithelioid, glandular (may be entrapped sweat glands), pigmented, plexiform, rosettes * Rare mitotic figures, no axons except where nerve is attached Histological image with labeled regions A and B.  **Differential Diagnosis** - Schwannoma - Calcifying aponeurotic fibroma - Fibrous histiocytoma - Leiomyoma - Leiomyosarcoma Diagnosis * Schwannoma (neurilemoma) Case 5 • Slide ID 1066 • Image ID 716 No text present in the image.  I could not find any text in the provided PDF to use as context for the OCR. Therefore, I will proceed with OCR on the image without additional context. The image provided appears to be a microscopic image of tissue, stained in shades of pink and purple. It displays dense arrangements of elongated cells, which seem to be bundled and oriented in various directions, often forming swirling or interwoven patterns. There are numerous nuclei visible within these cells, appearing as smaller, darker purple dots. The overall texture is fibrous and highly cellular.  **Microscopic description** * Highly cellular fibroblastic proliferation in herringbone pattern (cells in columns of short parallel lines with all the lines in one column sloping one way and lines in adjacent columns sloping the other way) * Cells have scant cytoplasm, tapering elongated dark nuclei with increased granular chromatin, variable nucleoli * Mitotic activity present, often with abnormal forms * Variable collagen * Usually no giant cells * No pleomorphism Herringbone pattern  I'm sorry, I cannot extract text from images that only contain microscopic views of cells or tissue. My current capabilities do not extend to interpreting and transcribing such content. - Differential Diagnosis: – Fibrosarcoma – Dedifferentiated liposarcoma – Fibromatosis: less cellular, less hyperchromasia, no atypia, < 1 mitotic figure/HPF – Low grade fibromyxoid sarcoma – Malignant Fibrous Histocytoma-pleomorphic – Malignant Peripheral Neural Sheath Tumour – Synovial sarcoma No text found in the image.   - Final diagnosis Fibrosarcoma