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Oral Pathology - 18 - Bone Malignant Lesions

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Oral Pathology1

  • Radiographic features are noted for diffuse borders and can cause erosion of the inferior border of the mandible.
  • The "round cells" involved are undifferentiated mesenchymal cells.
  • The preference for the condyle is due to the condylar cartilage originating separately from the rest of the mandible.

Clinical Significance of Paresthesia

Numb lip or paresthesia is the most frequent presenting symptom and a cardinal sign of malignancy. It can also present as dysesthesia, occurring when a malignancy neoplastically invades a nerve, causing nerve injury.

Table Of Contents

Clinical Classifications and Disease Categories2

  • Developmental Conditions
  • Mucosal Lesions—Reactive
  • Mucosal Lesions—Infections
  • Mucosal Lesions—Immunologic Diseases
  • Mucosal Lesions—Premalignant
  • Mucosal Lesions—Malignant
  • CT Tumors—Benign
  • CT Tumors—Malignant
  • Salivary Gland Diseases—Reactive
  • Salivary Gland Diseases—Benign
  • Salivary Gland Diseases—Malignant
  • Lymphoid Neoplasms
  • Odontogenic Cysts
  • Odontogenic Tumors
  • Bone Lesions—Fibro-Osseous
  • Bone Lesions—Giant Cell
  • Bone Lesions—Inflammatory
  • Bone Lesions—Malignant
  • Hereditary Conditions

Malignant Connective Tissue Tumors

Clinical and Radiographic Features3

  • Sarcoma of the jaws characterized by the production of new bone by tumor cells.
  • Radiographically presents with a classic “sunburst” pattern.
  • Malignancies in bone include sarcomas, lymphomas, leukemias, and metastatic carcinomas.
  • General treatment typically requires a combination of surgical resection, chemotherapy, and/or radiation therapy.

Osteosarcoma

Prognosis and Treatment

  • The 5-year survival rate is approximately 25-40%.
  • Treatment involves surgical resection combined with chemotherapy.

Chondrosarcoma

Pathophysiology and Location4

  • A sarcoma of the jaws where new cartilage is produced by the tumor cells.
  • Frequently involves the condyle due to its cartilaginous origin.

Presentation and Management

  • Shares the same clinical presentation and treatment protocols as osteosarcoma.

Ewing Sarcoma

Disease Characteristics5

  • A sarcoma primarily of the long bones involving “round cells.”
  • Typically affects children.

Clinical Presentation

  • Characterized by swelling.
  • Seldom affects the jaws.

Metastatic Carcinoma

Clinical Symptoms6

  • Patients often present with pain, swelling, and especially paresthesia.
  • Radiographic findings typically show ill-defined changes.

Primary Source Prevalence

  • The most common primary sites that metastasize to the jaws are ranked as follows:
    1. Breast
    2. Lung
    3. Kidney
    4. Colon
    5. Prostate

Footnotes

  1. Original PDF page 1: Oral Pathology - 18 - Bone Malignant Lesions, p.1 ↩

  2. Original PDF page 2: Oral Pathology - 18 - Bone Malignant Lesions, p.2 ↩

  3. Original PDF page 3: Oral Pathology - 18 - Bone Malignant Lesions, p.3 ↩

  4. Original PDF page 4: Oral Pathology - 18 - Bone Malignant Lesions, p.4 ↩

  5. Original PDF page 5: Oral Pathology - 18 - Bone Malignant Lesions, p.5 ↩

  6. Original PDF page 6: Oral Pathology - 18 - Bone Malignant Lesions, p.6 ↩

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